To request a trainer device or to discuss the patient assistance program, please call 1-877-SYMJEPI (1-877-796-5374)


Below are the answers to some of the most
frequently asked questions about SYMJEPI® (epinephrine) Injection

SYMJEPI is used to treat severe, potentially life-threatening allergic reactions, or anaphylaxis. It delivers the same medicine as in the epinephrine auto-injectors (EAIs) you may be used to but in a small, portable, and easy-to-use device.

While SYMJEPI and EAIs are both used to treat severe allergic reactions, the devices used to give an injection are different. The SYMJEPI device is a single-dose, disposable, pre-filled syringe, unlike the spring-loaded syringe of an auto-injector. Because of this design, which allows the user to control the injection, there is no need to thrust the device into the thigh as is required with an EAI, which may reduce the risk of an injection-related injury. Furthermore, the SYMJEPI device is smaller and easier to carry with you, has a thinner needle than those in the most widely used EAIs, and features a safety guard to keep users protected after an injection has been given.

Common symptoms of anaphylaxis include severe itching, trouble breathing, wheezing, swelling of the lips and mouth, hives, and dizziness or fainting. However, the reaction affects everyone differently, so it's a good idea to be aware of all the different symptoms of an anaphylactic reaction. Be sure to check out the Anaphylaxis Overview section to learn more.

SYMJEPI is a simple device that allows you to inject epinephrine into the middle of the outer thigh when an allergic emergency occurs. Before using SYMJEPI, please familiarize yourself with the steps to giving an injection or watch the SYMJEPI instructional video.

SYMJEPI should ONLY be injected into the middle of the outer thigh. Do not inject into your vein, buttocks, fingers, toes, hands, or feet. If an accident happens and you inject SYMJEPI into another part of your body, please seek medical treatment immediately.

Yes, SYMJEPI was designed to work effectively even when injected through clothing.

Talk to your doctor about how to spot the symptoms of anaphylaxis and how to decide when to take SYMJEPI. Only your doctor can accurately assess the risk of anaphylaxis and help you map out an Anaphylaxis Action Plan.

While 1 SYMJEPI device contains a full dose of epinephrine, it may be necessary to use the second device if the symptoms continue or recur. Seek immediate medical attention after using SYMJEPI and be sure to tell them that you have received an epinephrine injection.

SYMJEPI was designed to be easy to carry with you. It can fit in your pocket or purse when you're on the go, so you're never far from it should an allergic reaction happen. You are also encouraged to keep a SYMJEPI device wherever you or your child spends the most time, such as at school, work, and home.

While SYMJEPI is designed to be carried with you, the epinephrine in SYMJEPI is light sensitive and should be stored between 68°F and 77°F (20°C and 25°C).

Because an anaphylactic reaction can occur within minutes of exposure to an allergen, it's critical to carry your SYMJEPI with you at all times. To make this easier, you'll receive 2 SYMJEPI devices in a convenient carrying case with each prescription. This case can be separated if needed, but carry both devices with you in the event that the first dose does not fully relieve your symptoms.

Yes! A training device that features a fake needle is available for practice. Order one here.

The epinephrine in your SYMJEPI devices has an expiration date. Be sure to replace your SYMJEPI before this date, which can be found on the back of the carrying case, on the back of the device itself, and on the outer box.

  • It's a good idea to check the devices' window periodically to make sure that the liquid is clear and colorless. If you see that it is discolored (pinkish or brown), cloudy, or contains particles, you should bring it to your doctor immediately and replace the SYMJEPI device

No, SYMJEPI cannot be reused. Some medicine may be left in the device but the correct dose has been injected if the plunger has been pushed all the way down and the window is at least partially blocked. The second device in your pack is there in case the first dose does not work fully on the reaction. Seek immediate medical attention after using SYMJEPI to make sure you are safe.

Take all used or expired SYMJEPI devices to your doctor or a hospital for proper disposal. Do NOT throw SYMJEPI in the garbage.

The epinephrine inside SYMJEPI should be clear and colorless. If you see that it is discolored (pinkish or brown), cloudy, or contains particles, you should bring it to your doctor immediately and replace the SYMJEPI device.

IMPORTANT NOTE: The health information contained above is provided for general educational purposes only. Please consult with your healthcare professional if you have any questions about your allergies or SYMJEPI.

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full Important Safety Information


SYMJEPI is indicated in the emergency treatment of allergic reactions (Type 1) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which include bees, wasps, hornets, yellow jackets and fire ants) and biting insects (e.g., triatoma, mosquitoes), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media) and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.

Important Safety Information


Warnings and Precautions

  • You should get emergency medical care right away after using SYMJEPI.
  • You may need to use a second SYMJEPI (epinephrine) injection if symptoms continue or recur. Only a healthcare provider should give additional doses of epinephrine if you need more than 2 injections for a single anaphylaxis episode.
  • SYMJEPI should only be injected into the middle of your outer thigh (upper leg) with the needle facing downwards. Never inject into any other part of the body. If you accidentally inject SYMJEPI into any other part of your body, go to the nearest emergency room right away. Tell the healthcare provider where on your body you received the accidental injection. SYMJEPI can be injected through your clothing if needed.
  • The needle cap on the SYMJEPI prefilled syringe helps to prevent needle sticks and accidental injection of epinephrine. Do not remove the needle cap until you are ready to use it.
  • Never put your thumb, fingers, or hand over the exposed needle.
  • If an accidental injection happens, get medical help right away.
  • Do not drop the carrier case or SYMJEPI prefilled syringe. If the carrier case or prefilled syringe is dropped, check for damage and leakage. Dispose of the prefilled syringe and carrier case, and replace if damage or leakage is noticed or suspected.
  • Do not place patient information or any other foreign objects in the carrier case with the prefilled syringe, as this may prevent you from removing the prefilled syringe for use.
  • If you inject a young child with SYMJEPI, hold their leg firmly in place before and during the injection to prevent injuries. Ask your healthcare provider to show you how to properly hold the leg of a young child during injection.
  • Before using SYMJEPI, tell your healthcare provider about all of your medical conditions, including if you:
    • have heart problems or high blood pressure.
    • have diabetes.
    • have thyroid problems.
    • have asthma.
    • have a history of depression.
    • have Parkinson’s disease.
    • are pregnant or plan to become pregnant. It is not known if epinephrine will harm your unborn baby.
    • are breastfeeding or plan to breastfeed. It is not known if epinephrine passes into your breast milk.

Adverse Reactions
SYMJEPI may cause serious side effects.

  • Rarely, patients who have used SYMJEPI may develop infections at the injection site within a few days of an injection. Some of these infections can be serious. Call your healthcare provider right away if you have any of the following at an injection site:
    • redness that does not go away
    • swelling
    • tenderness
    • the area feels warm to the touch
  • Cuts on the skin, bent needles, and needles that remain in the skin after the injection, have happened in young children who do not cooperate and kick or move during the injection.
  • If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use your SYMJEPI. Talk to your healthcare provider about all your medical conditions.

Common side effects of SYMJEPI include:

  • fast, irregular or “pounding” heartbeat
  • sweating
  • headache
  • weakness
  • shakiness
  • paleness
  • feelings of over excitement, nervousness or anxiety
  • dizziness
  • nausea and vomiting
  • breathing problems

These side effects may go away with rest. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SYMJEPI. For more information, ask your healthcare provider or pharmacist.

Drug Interactions

  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • Tell your healthcare provider of all known allergies.
  • Especially tell your healthcare provider if you take certain asthma medicines.
  • SYMJEPI and other medicines may affect each other, causing side effects. SYMJEPI may affect the way other medicines work, and other medicines may affect how SYMJEPI works.
  • Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Please see full Prescribing Information for SYMJEPI.

To report SUSPECTED ADVERSE REACTIONS, contact Adamis Pharmaceuticals Corporation at 1-800-230-3935 or FDA at 1-800-FDA-1088 or

Important Safety Information

Warnings and Precautions

  • You should get emergency medical care right away after using SYMJEPI.
For any supply questions, please call 1-800-230-3935
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